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Breakthroughs in the ability to probe and better understand biologic systems in the past 30 years1-3 have enabled the medical community to build up new restorative agents and alter the course of many life-shortening diseases. 4, 5 Naturally success, bridging the gap between promising laboratory observations and the development of effective therapies remains risky and expensive, with fewer than 1 in 10, 1000 early translational programs effectively obtaining Food and Drug Administration (FDA) acceptance, at a cost of almost $1 billion. 6 Most therapeutic development fails in the preclinical phase, which is sometimes described as the "valley of death. "7
For this reason and because therapies for some conditions will have a limited eventual market value, the pharmaceutical industry has been not wanting to initiate early-stage programs to take care of so-called orphan diseases. In recognition of a critical need, federal firms have developed programs to catalyze innovation and minimize obstacles to early progress new therapies. 8 Previously two decades, disease-focused foundations also provide developed a new approach to bridging this preclinical gap. Inside a process known as venture philanthropy, such foundations have formed partnerships with industry and federal government agencies to talk about the financial risk of therapeutic development, shorten the early translational pipeline, and advance research with "a give attention to human, not financial, return. "9 In addition, foundations and their academic partners have accelerated early development by providing access to patient populations for clinical trials and assistance from disease-specific experts in study design, which has helped in bridging the gap in therapeutic development.
Within this review, we will concentrate on three diseases -- cystic fibrosis, multiple myeloma, and type 1 diabetes mellitus -- to illustrate how collaborations among academic institutions, footings, and industry partners have evolved to address the therapeutic challenges of these conditions.
CYSTIC FIBROSIS
Within 1989, the discovery of the gene that causes cystic fibrosis and the cystic fibrosis transmembrane conductance regulator (CFTR) protein10, 10 greatly increased interest within the scientific community in this life-shortening genetic disease, which impacts approximately 70, 000 patients worldwide. With support from the Cystic Fibrosis Foundation (CFF) and the National Institutes of Health (NIH), researchers rapidly expanded knowledge about the biogenesis, maturation, and function of CFTR, a regulated epithelial anion channel12; such knowledge provided the necessary scientific framework for the development of therapeutic focuses on. In addition, an international consortium13 discovered more than 1700 mutations and defined genotype-phenotype correlations with standard case definitions, 14 which enabled a precision-medicine method to therapeutic development. Inside the 1990s, attempts were made to treat cystic fibrosis by gene-replacement remedy provided to airway epithelia. Even though early in vitro15 and in vivo studies16 provided proof of concept, many barriers, including a strong host immune response, were encountered. 17 These limitations ended such initial scientific development programs.
In the decade following your discovery of the cystic fibrosis gene, scientific knowledge expanded but did not lead to a remedy that corrected CFTR function. In 1999, the CFF launched the Healing Development Program (TDP) to attract both academic and industry partners also to start high-throughput screening for CFTR modulators. 18, 19 The CFF embraced the concept of venture philanthropy9, 20 to improve the interest of industry in an orphan disease. However, the success of the TDP was centered on much more than financial support. 21 The program created a cultural shift that allowed the CFF, academic clinicians and scientists, federal agencies (the NIH and FDA), and industry to create a strong partnership with common goals and timelines.

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